MIRECC / CoE

Michael W Weiner, MD

Dr. Weiner completed his M.D at SUNY Upstate Medical Center Syracuse in 1965, his internship and residency at Mt. Sinai Hospital in 1967, and a residency and clinical fellowship in at the New Haven VA and Yale-New Haven Medical Center in 1968. He had various fellowships, earning Assistant Professorship at Stanford in 1974 while at the Palo Alto VA, and Associate Professorship at UCSF while at the San Francisco VA. In 1980 he was one of the first to perform MRS on an intact animal and subsequently pursued development of MRI/MRS as a clinical tool. In 1983, he established the Magnetic Resonance Unit at the San Francisco VA Medical Center. This evolved to become the Center for Imaging of Neurodegenerative Diseases and the VA Advanced Imaging Research Center with a 3T and 7 T MRI focused on research. Since 1990, he’s been a Professor in Radiology, Medicine, Psychiatry and Neurology at UCSF, while based at the San Francisco VA Medical Center.

Dr. Weiner has published 931 peer-reviewed articles, holds 19 separate research grants, and has received numerous honors. Importantly he received the national VA Middleton Award for outstanding research in the VA. In 2010, he was named one of the “Rock Stars of Science” in GQ magazine, and received the Gold Medal of Paul Sabatier University and the City of Toulouse, France. In 2011, he received the Ronald and Nancy Reagan Award for Research from the Alzheimer’s Association; in 2013, the Potamkin Prize for Research in Picks Disease, Alzheimer’s Disease and other Neurodegenerative Disorders from the American Association of Neurology and the American Brain Foundation; in 2014 the Distinguished Investigator Award from Academy of Radiology Research; in 2018, an Honorary Professorship Award from Australian Catholic University; in 2019, a Docteur Honoris Causa Degree from Paul Sabatier University, Toulouse, France, and in 2021, the Henry Wisniewski Lifetime Achievement Award in Alzheimer's Disease Research, from the Alzheimer's Association.

Research Interests

Dr. Weiner has been conducting research while working full time in the Veterans Administration since. 1970. He is currently Principal Investigator of the Alzheimer's Disease Neuroimaging Initiative (ADNI), the largest observational study of Alzheimer’s disease. Dr. Weiner’s research largely focuses on treatment to slow progression in Alzheimer’s disease, and on early detection and prevention.

Grants

R33AG062867
Weiner (PI)
04/15/20-02/28/25
The Brain Health Registry for facilitating interdisciplinary aging research

19-10538
Weiner (PI)
04/01/20-06/30/22
California Latino Brain Health Registry (CAL-BHR)

U19AG024904
Weiner (PI)
09/15/16-07/31/21
Alzheimer’s Disease Neuroimaging Initiative 3

W81XWH-14-1-0462
Weiner (PI)
09/22/14-09/21/21
Effects of Traumatic Brain Injury and Post-Traumatic Stress Disorder and Alzheimer’s Disease on Brain Tau in Vietnam Veterans using ADNI

MIRECC VISN 21
Weiner (PI)
10/01/98-09/30/21
Mental Illness Research, Education and Clinical Center

U24AG057437
Aisen (PI)
09/01/18-08/31/22
NIH
Alzheimer's Clinical Trials Consortium (U24)

RF1AG059009
Weiner (PI)
09/01/18-06/30/23
Validation of Online Methods to Predict and Monitor Cognitive Decline

U2CAG060426
Gershon (PI)
07/01/18-05/31/23
The Mobile Toolbox for Monitoring Cognitive Function

R01AG058676
Masters (PI)
09/30/18-05/31/23
Investigating Alzheimer's dementia onset and progression in international

RF1AG062196-01
Raj et all (MPI)
03/01/19–12/31023
Network Modelling of Multimodal Dynamics in Alzheimer's Disease and Dementia

W81XWH-13-1-0259
Weiner (PI)
09/30/13-09/29/20
Effects of traumatic brain injury and post-traumatic stress disorder on Alzheimer’s disease (AD) in Veterans with mild cognitive impairment using ADNI

W81XWH-12-2-0012
Weiner (PI)
02/21/12-09/29/20
Effects of Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD) on Alzheimer's Disease (AD) in Veterans Using Imaging and Biomarkers in the AD Neuroimaging Initiative (ADNI)

18-10929
Weiner (PI)
07/01/19-06/30/20
California Department of Public Health
Identifying Elders at Risk for Cognitive Decline Using the Brain Health Registry

18-PAF01312
Langa (Langa)
03/01/18-02/28/20
Health and Retirement Study Neuroimaging Pilot Study

Publications - Selected

1. Veitch DP, Weiner MW, Aisen P, Beckett LA, DeCarli C, Green RC, Harvey DJ, Jack C, Jagust W, Landau S, Morris J, Okonkwo O, Perrin R, Petersen RC, Rivera-Mindt M, Saykin A, Shaw LM, Toga A, Tosun D, Trojanowski JQ, Alzheimer' Dis Neuroimaging I. Utilizing the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease. Alzheimer's and Dementia. 2021. Epub In press
2. Jack CR Jr, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, Shaw LM, Vemuri P, Wiste HJ, Weigand SD, Lesnick TG, Pankratz VS, Donohue MC, Trojanowski JQ. Lancet Neurol, 12(2):207-16, 2013. PMCID: PMC3622225.
3. Weiner MW, Nosheny RL, Camacho M, Truran-Sacrey D, Mackin RS, Flenniken D, Ulbricht A, Insel PS, Finley S, Fockler J, Veitch D. The Brain Health Registry: An internet-based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies. Alzheimers Dement. 2018. doi: 10.1016/j.jalz.2018.02.021.
4. Weiner MW, Harvey D, Hayes J, Landau SM, Aisen PS, Petersen RC, Tosun D, Veitch DP, Jack CR, Jr., Decarli C, Saykin AJ, Grafman J, Neylan TC. Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary Report. Alzheimer's & dementia (New York, N Y). 2017;3(2):177-88
5. Keret O, Staffaroni AM, Ringman JM, Cobigo Y, Goh SM, Wolf A, Allen IE, Salloway S, Chhatwal J, Brickman AM, Reyes-Dumeyer D, Bateman RJ, Benzinger TLS, Morris JC, Ances BM, Joseph-Mathurin N, Perrin RJ, Gordon BA, Levin J, Vöglein J, Jucker M, la Fougère C, Martins RN, Sohrabi HR, Taddei K, Villemagne VL, Schofield PR, Brooks WS, Fulham M, Masters CL, Ghetti B, Saykin AJ, Jack CR, Graff-Radford NR, Weiner M, Cash DM, Allegri RF, Chrem P, Yi S, Miller BL, Rabinovici GD, Rosen HJ; Dominantly Inherited Alzheimer Network. Pattern and degree of individual brain atrophy predicts dementia onset in dominantly inherited Alzheimer's disease. Alzheimers Dement (Amst). 2021 Jul 5;13(1):e12197. doi: 10.1002/dad2.12197. PMID: 34258377; PMCID: PMC8256623.
6. Mackin RS, Rhodes E, Insel PS, Nosheny R, Finley S, Ashford M, Camacho MR, Truran D, Mosca K, Seabrook G, Morrison R, Narayan VA, Weiner M. Reliability and Validity of a Home-Based Self-Administered Computerized Test of Learning and Memory Using Speech Recognition. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2021 Jun 17:1-15. doi: 10.1080/13825585.2021.1927961. Epub ahead of print. PMID: 34139954.
7. Rhodes E, Insel PS, Butters MA, Morin R, Bickford D, Tosun D, Gessert D, Rosen HJ, Aisen P, Raman R, Landau S, Saykin A, Toga A, Jack CR, Weiner MW, Nelson C, Mackin S; Alzheimer’s Disease Neuroimaging Initiative; ADNI Depression Project. The Impact of Amyloid Burden and APOE on Rates of Cognitive Impairment in Late Life Depression. J Alzheimers Dis. 2021;80(3):991-1002. doi: 10.3233/JAD-201089. PMID: 33682706.
8. Veitch DP, Weiner MW, Aisen PS, Beckett LA, DeCarli C, Green RC, Harvey D, Jack CR Jr, Jagust W, Landau SM, Morris JC, Okonkwo O, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Trojanowski JQ; Alzheimer's Disease Neuroimaging Initiative. Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease. Alzheimers Dement. 2021 Sep 28. doi: 10.1002/alz.12422. Epub ahead of print. PMID: 34581485.
9. Risacher SL, West JD, Deardorff R, Gao S, Farlow MR, Brosch JR, Apostolova LG, McAllister TW, Wu YC, Jagust WJ, Landau SM, Weiner MW, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative#. Head injury is associated with tau deposition on PET in MCI and AD patients. Alzheimers Dement (Amst). 2021 Aug 24;13(1):e12230. doi: 10.1002/dad2.12230. PMID: 34466653; PMCID: PMC8383323.
10. Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR Jr, Jagust WJ, PetersenRC, Saykin AJ, Shaw LM, Trojanowski JQ, Weiner MW; Alzheimer's DiseaseNeuroimaging Initiative. Contribution of Alzheimer's biomarkers and risk factors tocognitive impairment and decline across the Alzheimer's disease continuum. Alzheimers Dement. 2021 Oct 14. doi: 10.1002/alz.12480. Epub ahead of print. PMID:34647694.
11. Albright J, Ashford MT, Jin C, Neuhaus J, Rabinovici GD, Truran D, Maruff P, MackinRS, Nosheny RL, Weiner MW. Machine learning approaches to predicting amyloidstatus using data from an online research and recruitment registry: The Brain HealthRegistry. Alzheimers Dement (Amst). 2021 Jun 9;13(1): e12207. doi:10.1002/dad2.12207. PMID: 34136635; PMCID: PMC8190559.
12. Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR Jr, Jagust WJ, Petersen RC, Saykin AJ, Shaw LM, Trojanowski JQ, Weiner MW; Alzheimer's Disease Neuroimaging Initiative. Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum. Alzheimers Dement. 2021 Oct 14. doi: 10.1002/alz.12480. Epub ahead of print. PMID: 34647694.
13. Shishegar R, Cox T, Rolls D, Bourgeat P, Doré V, Lamb F, Robertson J, Laws SM, Porter T, Fripp J, Tosun D, Maruff P, Savage G, Rowe CC, Masters CL, Weiner MW, Villemagne VL, Burnham SC. Using imputation to provide harmonized longitudinal measures of cognition across AIBL and ADNI. Sci Rep. 2021 Dec 10;11(1):23788. doi: 10.1038/s41598-021-02827-6. PMID: 34893624; PMCID: PMC8664816.
14. Karikari TK, Benedet AL, Ashton NJ, Lantero Rodriguez J, Snellman A, Suárez- Calvet M, Saha-Chaudhuri P, LussierF, Kvartsberg H, Rial AM, Pascoal TA, Andreasson U, Schöll M, Weiner MW, Rosa-Neto P, Trojanowski JQ, Shaw LM, Blennow K, Zetterberg H; Alzheimer’s Disease Neuroimaging Initiative. Diagnostic performance and prediction ofclinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative. Mol Psychiatry.2021 Feb;26(2):429-442. doi: 10.1038/s41380-020-00923-z. Epub 2020 Oct 26. PMID: 33106600.
15. Weber CJ, Carrillo MC, Jagust W, Jack CR Jr, Shaw LM, Trojanowski JQ, Saykin AJ, Beckett LA, Sur C, Rao NP, Mendez PC, Black SE, Li K, Iwatsubo T, Chang CC, Sosa AL, Rowe CC, Perrin RJ, Morris JC, Healan AMB, Hall SE, Weiner MW. The Worldwide Alzheimer's Disease Neuroimaging Initiative: ADNI-3 updates and global perspectives. Alzheimers Dement (N Y). 2021 Dec 31;7(1): e12226. doi: 10.1002/trc2.12226. PMID: 35005206; PMCID: PMC8719344.
16. Li Y, Schindler SE, Bollinger JG, Ovod V, Mawuenyega KG, Weiner MW, Leslie SM, Masters CL, Fowler CJ, Trojanowski JQ, Korecka M, Martins RN, Janelidze S, Hansson O, Bateman RJ. Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques. Neurology. 2021 Dec 14:10.1212/WNL.0000000000013211. doi: 10.1212/WNL.0000000000013211. Epub ahead of print. PMID: 34906975.
17. Albright J, Ashford MT, Jin C, Neuhaus J, Rabinovici GD, Truran D, Maruff P, Mackin RS, Nosheny RL, Weiner MW. Machine learning approaches to predicting amyloid status using data from an online research and recruitment registry: The Brain Health Registry. Alzheimers Dement (Amst). 2021 Jun 9;13(1): e12207. doi: 10.1002/dad2.12207. PMID: 34136635; PMCID: PMC8190559.
18. Weber CJ, Carrillo MC, Jagust W, Jack CR Jr, Shaw LM, Trojanowski JQ, Saykin AJ, Beckett LA, Sur C, Rao NP, Mendez PC, Black SE, Li K, Iwatsubo T, Chang CC, Sosa AL, Rowe CC, Perrin RJ, Morris JC, Healan AMB, Hall SE, Weiner MW. The Worldwide Alzheimer's Disease Neuroimaging Initiative: ADNI-3 updates and global perspectives. Alzheimers Dement (N Y). 2021 Dec 31;7(1):e12226. doi: 10.1002/trc2.12226. PMID: 35005206; PMCID: PMC8719344.
19. Li Y, Schindler SE, Bollinger JG, Ovod V, Mawuenyega KG, Weiner MW, Leslie SM, Masters CL, Fowler CJ, Trojanowski JQ, Korecka M, Martins RN, Janelidze S, Hansson O, Bateman RJ. Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques. Neurology. 2021 Dec 14:10.1212/WNL.0000000000013211. doi: 10.1212/WNL.0000000000013211. Epub ahead of print. PMID: 34906975.
20. Shishegar R, Cox T, Rolls D, Bourgeat P, Doré V, Lamb F, Robertson J, Laws SM, Porter T, Fripp J, Tosun D, Maruff P, Savage G, Rowe CC, Masters CL, Weiner MW, Villemagne VL, Burnham SC. Using imputation to provide harmonized longitudinal measures of cognition across AIBL and ADNI. Sci Rep. 2021 Dec 10;11(1):23788. doi: 10.1038/s41598-021-02827-6. PMID: 34893624; PMCID: PMC8664816.
21. Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR Jr, Jagust WJ, Petersen RC, Saykin AJ, Shaw LM, Trojanowski JQ, Weiner MW; Alzheimer's Disease Neuroimaging Initiative. Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum. Alzheimers Dement. 2021 Oct 14. doi: 10.1002/alz.12480. Epub ahead of print. PMID: 34647694.
22. Jones KS, Chapman AE, Driscoll HA, Fuller EP, Kelly M, Li X, Mansour S, McBride SL, Zhao Q, Weiner M, Ferguson MR. MILKSHAKE: novel validation method for antibodies to post-translationally modified targets by surrogate Western blot. Biotechniques. 2022 Jan;72(1):11-20. doi: 10.2144/btn-2021-0078. Epub 2021 Nov 29. PMID: 34841898.
23. Zhao Q, Chapman A, Huang Y, Ferguson M, McBride S, Kelly M, Weiner M, Li X. Ligand-Directed GPCR Antibody Discovery. Methods Mol Biol. 2022;2394:319-342. doi: 10.1007/978-1-0716-1811-0_19. PMID: 35094336.

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