Vahram Haroutunian, PhD - MIRECC / CoE
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Vahram Haroutunian, PhD

After completing a postdoctoral training program at Princeton concentrating on research in development and in aging in 1982, Dr. Haroutunian joined the faculty at the James J Peters VA Medical Center and the Icahn School of Medicine at Mount Sinai. He has served as the Interim Director of the JJ Peters VA Medical Center MIRECC and is the Director for Research within the MIRECC. He has directed the Division of Basic and Laboratory Science in the Department of Psychiatry, the Alzheimer’s disease and Schizophrenia Brain Bank, a National Institute of Aging Program Project grant entitled Clinical and Biological Studies of Early Alzheimer’s disease, multiple NIH R01s, U01s and Veterans Affairs Merit grants on the neurobiology of aging, Alzheimer’s disease, and schizophrenia. He is the director of one of the 6 national NIH Neurobiobanks, located at the James J Peters VA. He has also been a major contributor to Mount Sinai’s Silvio Conte Center for Neuroscience and the Alzheimer’s Disease Research Center.

In the past decade, Dr. Haroutunian’s research has centered on the molecular and neuropathological correlated of schizophrenia, dementia, and healthy aging. He uses molecular biological techniques, including microarray and RNA-seq technology, and neuropathological studies to understand the biological substrates of mental illness dementia, and healthy aging. Dr. Haroutunian uses postmortem human brain and genetically modified mouse model systems to study cell-type-specific molecular feature of the human brain.


Research Interests

Schizophrenia, depression, suicide, neurobiology, Alzheimer’s disease, healthy aging, cell-type specific gene expression


Grants

The 3D Genome in Transcriptional Regulation Across The Postnatal Life Span, With Implications for Schizophrenia and Bipolar Disorder (2018-2023)

Role: Principal investigator. Funding source: NIMH.

 

Sheep Request for Fluorescence Activated Cell Sorter (FACS; MOFLO ASTRIOS EQ) (2018)

Role: Principal investigator. Funding source: VA.

 

Integrative Network Modeling of Cognitive Resilience to Alzheimer's Disease (2017-2022)

Role: Principal investigator. Funding source: NIA.

 

Towards a Comprehensive Signaling Pathway Map of Parahippocampal Vulnerability in Alzheimers Disease (2017-2020)

Role: Principal investigator. Funding source: NIA.

 

Core D - Neuropathology (2016-2017)

Role: Principal investigator. Funding source: NIA.

 

IGF::OT::IGF (2016-2017)

Role: Principal investigator. Funding source: NIMH.

 

Sheep Grant Application: Digital Histology and Microscopy for Human and Animal Tissue (2016)

Role: Principal investigator. Funding source: VA.

 

Neurobiological Mechanisms of Reduced Ad-Neuropathology by Treatment of Diabetes (2014-2018)

Role: Principal investigator. Funding source: VA.

 

Integrative Biology Approach to Complexity of Alzheimer's Disease (2013-2017)

Role: Principal investigator. Funding source: NIA.

 

NIMH, NICHD, and NINDS Brain and Tissue Repository (2013-2014)

Role: Principal investigator. Funding source: NIMH.

 

P5-Mouse Phenotyping (2011-2013) p>

Role: Principal investigator. Funding source: NIMH.

 

Core B-Clinical/Brain Bank Core (2011-2013)

Role: Principal investigator. Funding source: NIMH.

 

Core C-Data Management And Statistics (2008-2012)

Role: Principal investigator. Funding source: NIMH.

 

Core--Data Management (2007-2008)

Role: Principal investigator. Funding source: NIA.

 

Data Management and Statistics Core (2006-2007)

Role: Principal investigator. Funding source: NIA.

 

Contribution of Cell Cycle Processes to Myelin Deficits in Schizophrenia (2003-2013) 

Role: Principal investigator. Funding source: NIMH.

 

Cortico-Thalamic Glutamate/GABA MRNA in Schizophrenia (2003-2008)

Role: Principal investigator. Funding source: NIMH.

 

Core-- Brain Bank (1996)

Role: Principal investigator. Funding source: NIA.

 

Neurofilament Mid-Sized Transgenic Mouse as a Model for Alzheimer's Disease (1994)

Role: Principal investigator. Funding source: NIA.

 

Synthesis of B-App in Transmitter Deficient Models of AD (1992-1995)

Role: Principal investigator. Funding source: NIA.

 

Toward an Animal Model of Alzheimer Disease (1986)

Role: Principal investigator. Funding source: NIA.


In the News

Breakthrough Alzheimer’s treatment hinges on diabetes drugs: study (NY Post, November 2018)

Diabetes Meds May Reduce Alzheimer's Pathology (Medscape, November 2018)

Brains in the Bronx (Reuters, August 2017)

Inside a human brain bank, where frozen tubs preserve slices of spongy tissue (Business Insider, August 2017)

Inside the Bronx's human brain bank (NY Daily News, June 2017)

Meet the Brain Banker Who Keeps Thousands of Brains In His Lab In the Bronx (Atlas Obscura, February 2016)

Research shifts to examine role of myelin and suggests new therapies may be on the horizon (Newsday, March 2003)


Publications (Selected)

A full list of Dr. Haroutunian’s publications can be found here.

Katsel P, Roussos P, Beeri MS, Gama-Sosa MS, Gandy S, Khan S, Haroutunian V. Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer’s disease and normalized by treatment with anti-diabetic agents. PloS ONE, 2018.

Katsel P, Roussos P, Pletnikov M, Haroutunian V. Microvascular anomaly conditions in psychiatric disease. Schizophrenia - angiogenesis connection. Neuroscience and Biobehavioral Reviews, 2017.

Fullard JF, Halene TB, Giambartolomei C, Haroutunian V, Akbarian S, Roussos P.Understanding the genetic liability to schizophrenia through the neuroepigenome. Schizophrenia Research, 2016.

Haroutunian V, Katsel P, Roussos P, Davis KL, Altshuler LL, Bartzokis G. Myelination, oligodendrocytes, and serious mental illness. Glia, 2014.

Roussos P, Katsel P, Davis KL, Siever LJ, Haroutunian V. A system-level transcriptomic analysis of schizophrenia using postmortem brain tissue samples. Archives of General Psychiatry, 2012.

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