Panagiotis Roussos, MD, PhD - MIRECC / CoE
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Panagiotis Roussos, MD, PhD

Dr. Roussos is an associate professor of Psychiatry and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. He received his medical and doctorate degrees from the University of Crete in Greece and he completed his residency in Psychiatry (research track) at Icahn School of Medicine at Mount Sinai followed by a MIRECC research fellowship in schizophrenia. His early research focused on the genetic exploration of intermediate cognitive phenotypes, including the prepulse inhibition of the startle reflex in human subjects and restoration of deficits using a pharmacogenomic approach. During his residency in psychiatry (Physician-Scientist Research Track) at Icahn School of Medicine at Mount Sinai, he worked on human postmortem studies by integrating genomics with gene expression and gene network approaches

Dr. Roussos's research focuses on the integration of high-dimensional data, such as genomic, epigenomic and transcriptomic, using advanced biostatistical methods in order to identify some of the mechanisms through which risk genetic variants increase the risk for neuropsychiatric diseases. He applies a combination of molecular biology and bioinformatics approaches to tackle these questions.


Research Interests

Schizophrenia, genetics


Grants  

The 3D Genome in Transcriptional Regulation Across the Postnatal Life Span, With Implications for Schizophrenia and Bipolar Disorder (2018-2023)
Role: Principal investigator


Dissecting Cis Regulation of Gene Expression in Schizophrenia (2013-2022)
Role: Principal investigator


Integrated Multiscale Networks in Schizophrenia (2016-2021)
Role: Principal investigator


Presidential Early Career Awards for Scientists and Engineers (PECASE) (2016-2021)


Risk Genetic Variants and Cis Regulation of Gene Expression in Bipolar Disorder (2016-2021)
Role: Principal investigator


Large-Scale Transcriptome and Epigenome Association Analysis Across Multiple Traits (2018-2020)
Role: Principal investigator


Towards a comprehensive Signaling Pathway Map of Parahippocampal Vulnerability in Alzheimer’s Disease (2017-2020)
Role: Principal investigator


Molecular Profiling of Schizophrenia (2016-2020)
Role: Principal investigator


Higher Order Chromatin and Genetic Risk for Alzheimer's Disease (2015-2020)
Role: Principal investigator


Multiregional Assessment of Cell Type Specific Epigenome and Transcriptional Profiling in Human Brain Tissue (2017-2019)
Role: Principal investigator


Higher Order Chromatin and Genetic Risk for Schizophrenia (2015-2018)
Role: Principal investigator


In the News  

First common risk genes discovered for autism (Science Daily, February 2019)

Scientists create genomic resource to explore biological underpinnings of brain disorders (Science Daily, December 2018)

First risk genes for ADHD found (Science Daily, November 2018)


Featured Publications  

Below is a selection of Dr. Roussos’ publications; the full list can be found here.

Fullard JF, Charney AW, Voloudakis G, Uzilov AV, Haroutunian V, Roussos P. Assessment of somatic single-nucleotide variation in brain tissue of cases with schizophrenia. Translational Psychiatry, 2019.  

Fullard JF, Hauberg ME, Bendl J, Egervari G, Cirnaru MD, Reach SM, Motl J, Ehrlich ME, Hurd YL, Roussos P. An atlas of chromatin accessibility in the adult human brain. Genome Research, 2018.  

Giambartolomei C, Zhenli Liu J, Zhang W, Hauberg M, Shi H, Boocock J, Pickrell J, Jaffe AE; CommonMind Consortium, Pasaniuc B, Roussos P. A bayesian framework for multiple trait colo-calization from summary association statistics. Bioinformatics, 2018.  

Quednow BB, Ejebe K, Wagner M, Giakoumaki SG, Bitsios P, Kumari V, Roussos P. Meta-analysis on the association between genetic polymorphisms and prepulse inhibition of the acoustic startle response.
Schizophrenia Research, 2017.  

Hauberg ME, Zhang W, Giambartolomei C, Franzén O, Morris DL, Vyse TJ, Ruusalepp A; CommonMind Consortium, Sklar P, Schadt EE, Björkegren JLM, Roussos P. Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression. The American Journal of Human Genetics, 2017.

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